Outline of male pattern baldness

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Outline of "male pattern baldness" Outline of alopecia



Outline of "male pattern baldness" Outline of alopecia


The detailed mechanism of "male pattern baldness" must know the relationship with "male hormone". First, at the age of adolescents, beards and chest hair, which were "fostale hair" when they were children, will become hard hair with the power of male hormones.


A When this hormone circulates through the blood and enters into the cells that make hair, the enzyme "5α-reductase" works and turns into a hair loss bad "Dihydrotesterone" (DHT).
B This bad DHT enters into the cells that make hair bad and received it by male hormone receptor that accepts this substance and has information to make the target gene promoter, that is, the targeted prey hair Sticking to the gene, annoying things happen.
C It do inconsistent work there. All this effect is the target of hair dermal papilla cells at the base of the hair making hair. When you encounter hair like beard, axillary hair etc., you can make "growth factor" called "TGF-1". However, when it comes to an important forelock, that is, a "frontal lobe" hair papilla cell, a factor called "TGF-β1" comes out and disturbs growing the hair stiff or causes the worst "necrosis of the cell" . In other words, it becomes a "bad monster".
D It has beard, axillary hair, forehead, head top, etc that have this troublesome
receptor, but this receptor is not in the back of the head, in the temporal part. So it will stay. It is the reason why sideways and behind are left behind like japanese animation charactor "Sazaesan's father".


Beard and axillary hair have such growth function, but it will cause hair loss when it comes to the hair part of the important head. Since there is no other (receptor, itself) in the back of the head and the temporal part other than that, it can not cause hair loss.
People whose head hair is forever remain genetically, as there is no receptor,that dan't receives bad factors in the forehead, parietal region etc, so that the hair remains.
Recently, there are "transplanted hair" which transplant the hair of the occipital part, the temporal part where the hair remained to the crown part and the forehead part, and the planted hair will continue to grow over the whole life.